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Title:

Nanoresolution real-time 3D orbital tracking for studying mitochondrial trafficking in vertebrate axons in vivo.

Document type:
Article; Journal Article
Author(s):
Wehnekamp, Fabian; Plucińska, Gabriela; Thong, Rachel; Misgeld, Thomas; Lamb, Don C
Abstract:
We present the development and in vivo application of a feedback-based tracking microscope to follow individual mitochondria in sensory neurons of zebrafish larvae with nanometer precision and millisecond temporal resolution. By combining various technical improvements, we tracked individual mitochondria with unprecedented spatiotemporal resolution over distances of >100 µm. Using these nanoscopic trajectory data, we discriminated five motional states: a fast and a slow directional motion state...     »
Journal title abbreviation:
Elife
Year:
2019
Journal volume:
8
Fulltext / DOI:
doi:10.7554/eLife.46059
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31180320
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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