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Title:

A new form of axonal pathology in a spinal model of neuromyelitis optica.

Document type:
Article; Journal Article
Author(s):
Herwerth, Marina; Kenet, Selin; Schifferer, Martina; Winkler, Anne; Weber, Melanie; Snaidero, Nicolas; Wang, Mengzhe; Lohrberg, Melanie; Bennett, Jeffrey L; Stadelmann, Christine; Hemmer, Bernhard; Misgeld, Thomas
Abstract:
Neuromyelitis optica is a chronic neuroinflammatory disease, which primarily targets astrocytes and often results in severe axon injury of unknown mechanism. Neuromyelitis optica patients harbour autoantibodies against the astrocytic water channel protein, aquaporin-4 (AQP4-IgG), which induce complement-mediated astrocyte lysis and subsequent axon damage. Using spinal in vivo imaging in a mouse model of such astrocytopathic lesions, we explored the mechanism underlying neuromyelitis optica-relat...     »
Journal title abbreviation:
Brain
Year:
2022
Journal volume:
145
Journal issue:
5
Pages contribution:
1726-1742
Fulltext / DOI:
doi:10.1093/brain/awac079
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35202467
Print-ISSN:
0006-8950
TUM Institution:
Klinik und Poliklinik für Neurologie; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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