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Title:

Microfluidics-Assisted Selective Depolarization of Axonal Mitochondria.

Document type:
Article; Journal Article; Video-Audio Media; Research Support, Non-U.S. Gov't
Author(s):
Wanderoy, Simone; Rühmkorf, Alina; Harbauer, Angelika B
Abstract:
Mitochondria are the primary suppliers of ATP (adenosine triphosphate) in neurons. Mitochondrial dysfunction is a common phenotype in many neurodegenerative diseases. Given some axons' elaborate architecture and extreme length, it is not surprising that mitochondria in axons can experience different environments compared to their cell body counterparts. Interestingly, dysfunction of axonal mitochondria often precedes effects on the cell body. To model axonal mitochondrial dysfunction in vitro, m...     »
Journal title abbreviation:
J Vis Exp
Year:
2022
Journal issue:
186
Fulltext / DOI:
doi:10.3791/64196
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35993756
Print-ISSN:
1940-087X
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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