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Title:

Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Fitzner, Dirk; Bader, Jakob M; Penkert, Horst; Bergner, Caroline G; Su, Minhui; Weil, Marie-Theres; Surma, Michal A; Mann, Matthias; Klose, Christian; Simons, Mikael
Abstract:
Gene and protein expression data provide useful resources for understanding brain function, but little is known about the lipid composition of the brain. Here, we perform quantitative shotgun lipidomics, which enables a cell-type-resolved assessment of the mouse brain lipid composition. We quantify around 700 lipid species and evaluate lipid features including fatty acyl chain length, hydroxylation, and number of acyl chain double bonds, thereby identifying cell-type- and brain-region-specific l...     »
Journal title abbreviation:
Cell Rep
Year:
2020
Journal volume:
32
Journal issue:
11
Fulltext / DOI:
doi:10.1016/j.celrep.2020.108132
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32937123
Print-ISSN:
2211-1247
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld); Neurologische Klinik und Poliklinik
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