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Title:

STIM1 controls neuronal Ca²? signaling, mGluR1-dependent synaptic transmission, and cerebellar motor behavior.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Hartmann, Jana; Karl, Rosa M; Alexander, Ryan P D; Adelsberger, Helmuth; Brill, Monika S; Rühlmann, Charlotta; Ansel, Anna; Sakimura, Kenji; Baba, Yoshihiro; Kurosaki, Tomohiro; Misgeld, Thomas; Konnerth, Arthur
Abstract:
In central mammalian neurons, activation of metabotropic glutamate receptor type1 (mGluR1) evokes a complex synaptic response consisting of IP3 receptor-dependent Ca(2+) release from internal Ca(2+) stores and a slow depolarizing potential involving TRPC3 channels. It is largely unclear how mGluR1 is linked to its downstream effectors. Here, we explored the role of stromal interaction molecule 1 (STIM1) in regulating neuronal Ca(2+) signaling and mGluR1-dependent synaptic transmission. By analyz...     »
Journal title abbreviation:
Neuron
Year:
2014
Journal volume:
82
Journal issue:
3
Pages contribution:
635-44
Language:
eng
Fulltext / DOI:
doi:10.1016/j.neuron.2014.03.027
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24811382
Print-ISSN:
0896-6273
TUM Institution:
Institut für Neurowissenschaften; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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