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Titel:

Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Marisca, Roberta; Hoche, Tobias; Agirre, Eneritz; Hoodless, Laura Jane; Barkey, Wenke; Auer, Franziska; Castelo-Branco, Gonçalo; Czopka, Tim
Abstract:
Recent reports have revealed that oligodendrocyte precursor cells (OPCs) are heterogeneous. It remains unclear whether such heterogeneity reflects different subtypes of cells with distinct functions or instead reflects transiently acquired states of cells with the same function. By integrating lineage formation of individual OPC clones, single-cell transcriptomics, calcium imaging and neural activity manipulation, we show that OPCs in the zebrafish spinal cord can be divided into two functionall...     »
Zeitschriftentitel:
Nat Neurosci
Jahr:
2020
Band / Volume:
23
Heft / Issue:
3
Seitenangaben Beitrag:
363-374
Volltext / DOI:
doi:10.1038/s41593-019-0581-2
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32066987
Print-ISSN:
1097-6256
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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