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Titel:

Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Fitzner, Dirk; Bader, Jakob M; Penkert, Horst; Bergner, Caroline G; Su, Minhui; Weil, Marie-Theres; Surma, Michal A; Mann, Matthias; Klose, Christian; Simons, Mikael
Abstract:
Gene and protein expression data provide useful resources for understanding brain function, but little is known about the lipid composition of the brain. Here, we perform quantitative shotgun lipidomics, which enables a cell-type-resolved assessment of the mouse brain lipid composition. We quantify around 700 lipid species and evaluate lipid features including fatty acyl chain length, hydroxylation, and number of acyl chain double bonds, thereby identifying cell-type- and brain-region-specific l...     »
Zeitschriftentitel:
Cell Rep
Jahr:
2020
Band / Volume:
32
Heft / Issue:
11
Volltext / DOI:
doi:10.1016/j.celrep.2020.108132
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32937123
Print-ISSN:
2211-1247
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld); Neurologische Klinik und Poliklinik
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