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Document type:
journal article 
Author(s):
Witte, Maarten E; Schumacher, Adrian-Minh; Mahler, Christoph F; Bewersdorf, Jan P; Lehmitz, Jonas; Scheiter, Alexander; Sánchez, Paula; Williams, Philip R; Griesbeck, Oliver; Naumann, Ronald; Misgeld, Thomas; Kerschensteiner, Martin 
Title:
Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis. 
Abstract:
Axon loss determines persistent disability in multiple sclerosis patients. Here, we use in vivo calcium imaging in a multiple sclerosis model to show that cytoplasmic calcium levels determine the choice between axon loss and survival. We rule out the endoplasmic reticulum, glutamate excitotoxicity, and the reversal of the sodium-calcium exchanger as sources of intra-axonal calcium accumulation and instead identify nanoscale ruptures of the axonal plasma membrane as the critical path of calcium e...    »
 
Journal title abbreviation:
Neuron 
Year:
2019 
Journal volume:
101 
Journal issue:
Pages contribution:
615-624.e5 
Language:
eng 
Print-ISSN:
0896-6273 
TUM Institution:
Institut für Zellbiologie des Nervensystems