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Titel:

Metabolic Regulation of Mitochondrial Protein Biogenesis from a Neuronal Perspective.

Dokumenttyp:
Review; Journal Article; Review; Research Support, Non-U.S. Gov't
Autor(en):
Hees, Jara Tabitha; Harbauer, Angelika Bettina
Abstract:
Neurons critically depend on mitochondria for ATP production and Ca2+ buffering. They are highly compartmentalized cells and therefore a finely tuned mitochondrial network constantly adapting to the local requirements is necessary. For neuronal maintenance, old or damaged mitochondria need to be degraded, while the functional mitochondrial pool needs to be replenished with freshly synthesized components. Mitochondrial biogenesis is known to be primarily regulated via the PGC-1α-NRF1/2-TFAM pathw...     »
Zeitschriftentitel:
Biomolecules
Jahr:
2022
Band / Volume:
12
Heft / Issue:
11
Volltext / DOI:
doi:10.3390/biom12111595
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36358945
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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