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Titel:

Ketogenic diet uncovers differential metabolic plasticity of brain cells.

Dokumenttyp:
Article; Journal Article
Autor(en):
Düking, Tim; Spieth, Lena; Berghoff, Stefan A; Piepkorn, Lars; Schmidke, Annika M; Mitkovski, Miso; Kannaiyan, Nirmal; Hosang, Leon; Scholz, Patricia; Shaib, Ali H; Schneider, Lennart V; Hesse, Dörte; Ruhwedel, Torben; Sun, Ting; Linhoff, Lisa; Trevisiol, Andrea; Köhler, Susanne; Pastor, Adrian Marti; Misgeld, Thomas; Sereda, Michael; Hassouna, Imam; Rossner, Moritz J; Odoardi, Francesca; Ischebeck, Till; de Hoz, Livia; Hirrlinger, Johannes; Jahn, Olaf; Saher, Gesine
Abstract:
To maintain homeostasis, the body, including the brain, reprograms its metabolism in response to altered nutrition or disease. However, the consequences of these challenges for the energy metabolism of the different brain cell types remain unknown. Here, we generated a proteome atlas of the major central nervous system (CNS) cell types from young and adult mice, after feeding the therapeutically relevant low-carbohydrate, high-fat ketogenic diet (KD) and during neuroinflammation. Under steady-st...     »
Zeitschriftentitel:
Sci Adv
Jahr:
2022
Band / Volume:
8
Heft / Issue:
37
Volltext / DOI:
doi:10.1126/sciadv.abo7639
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36112685
Print-ISSN:
2375-2548
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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