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Titel:

Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Strohm, Laura; Hu, Zehan; Suk, Yongwon; Rühmkorf, Alina; Sternburg, Erin; Gattringer, Vanessa; Riemenschneider, Henrick; Berutti, Riccardo; Graf, Elisabeth; Weishaupt, Jochen H; Brill, Monika S; Harbauer, Angelika B; Dormann, Dorothee; Dengjel, Jörn; Edbauer, Dieter; Behrends, Christian
Abstract:
Ubiquilin-2 (UBQLN2) is a ubiquitin-binding protein that shuttles ubiquitinated proteins to proteasomal and autophagic degradation. UBQLN2 mutations are genetically linked to the neurodegenerative disorders amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). However, it remains elusive how UBQLN2 mutations cause ALS/FTD. Here, we systematically examined proteomic and transcriptomic changes in patient-derived lymphoblasts and CRISPR/Cas9-engineered HeLa cells carrying ALS/FTD UBQ...     »
Zeitschriftentitel:
Life Sci Alliance
Jahr:
2022
Band / Volume:
5
Heft / Issue:
11
Volltext / DOI:
doi:10.26508/lsa.202101327
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35777956
TUM Einrichtung:
Institut für Humangenetik; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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