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Titel:

Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Cunha, Maria Inês; Su, Minhui; Cantuti-Castelvetri, Ludovico; Müller, Stephan A; Schifferer, Martina; Djannatian, Minou; Alexopoulos, Ioannis; van der Meer, Franziska; Winkler, Anne; van Ham, Tjakko J; Schmid, Bettina; Lichtenthaler, Stefan F; Stadelmann, Christine; Simons, Mikael
Abstract:
Remyelination requires innate immune system function, but how exactly microglia and macrophages clear myelin debris after injury and tailor a specific regenerative response is unclear. Here, we asked whether pro-inflammatory microglial/macrophage activation is required for this process. We established a novel toxin-based spinal cord model of de- and remyelination in zebrafish and showed that pro-inflammatory NF-κB-dependent activation in phagocytes occurs rapidly after myelin injury. We found th...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2020
Band / Volume:
217
Heft / Issue:
5
Volltext / DOI:
doi:10.1084/jem.20191390
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32078678
Print-ISSN:
0022-1007
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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