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Title:

Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Djannatian, Minou; Timmler, Sebastian; Arends, Martina; Luckner, Manja; Weil, Marie-Theres; Alexopoulos, Ioannis; Snaidero, Nicolas; Schmid, Bettina; Misgeld, Thomas; Möbius, Wiebke; Schifferer, Martina; Peles, Elior; Simons, Mikael
Abstract:
Central nervous system myelin is a multilayered membrane produced by oligodendrocytes to increase neural processing speed and efficiency, but the molecular mechanisms underlying axonal selection and myelin wrapping are unknown. Here, using combined morphological and molecular analyses in mice and zebrafish, we show that adhesion molecules of the paranodal and the internodal segment work synergistically using overlapping functions to regulate axonal interaction and myelin wrapping. In the absence...     »
Journal title abbreviation:
Nat Commun
Year:
2019
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-019-12789-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31641127
Print-ISSN:
2041-1723
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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