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Title:

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Cantuti-Castelvetri, Ludovico; Ojha, Ravi; Pedro, Liliana D; Djannatian, Minou; Franz, Jonas; Kuivanen, Suvi; van der Meer, Franziska; Kallio, Katri; Kaya, Tuğberk; Anastasina, Maria; Smura, Teemu; Levanov, Lev; Szirovicza, Leonora; Tobi, Allan; Kallio-Kokko, Hannimari; Österlund, Pamela; Joensuu, Merja; Meunier, Frédéric A; Butcher, Sarah J; Winkler, Martin Sebastian; Mollenhauer, Brit; Helenius, Ari; Gokce, Ozgun; Teesalu, Tambet; Hepojoki, Jussi; Vapalahti, Olli; Stadelmann, Christine; Balist...     »
Abstract:
The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue tropism is determined by the availability of virus receptors and entry cofactors on the surface of host cells. In this study, we found that neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked by a monoclonal blocking antibody against NRP1. A SARS-CoV-2 mutant with an al...     »
Journal title abbreviation:
Science
Year:
2020
Journal volume:
370
Journal issue:
6518
Pages contribution:
856-860
Fulltext / DOI:
doi:10.1126/science.abd2985
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33082293
Print-ISSN:
0036-8075
TUM Institution:
657; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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