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Title:

CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities.

Document type:
Journal Article; Review; Research Support, Non-U.S. Gov't
Author(s):
Franklin, Robin J M; Simons, Mikael
Abstract:
Remyelination, the myelin regenerative response that follows demyelination, restores saltatory conduction and function and sustains axon health. Its declining efficiency with disease progression in the chronic autoimmune disease multiple sclerosis (MS) contributes to the currently untreatable progressive phase of the disease. Although some of the bona fide myelin regenerative medicine clinical trials have succeeded in demonstrating proof-of-principle, none of these compounds have yet proceeded t...     »
Journal title abbreviation:
Neuron
Year:
2022
Journal volume:
110
Journal issue:
21
Pages contribution:
3549-3565
Fulltext / DOI:
doi:10.1016/j.neuron.2022.09.023
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36228613
Print-ISSN:
0896-6273
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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