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Titel:

Myelin replacement triggered by single-cell demyelination in mouse cortex.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Snaidero, Nicolas; Schifferer, Martina; Mezydlo, Aleksandra; Zalc, Bernard; Kerschensteiner, Martin; Misgeld, Thomas
Abstract:
Myelin, rather than being a static insulator of axons, is emerging as an active participant in circuit plasticity. This requires precise regulation of oligodendrocyte numbers and myelination patterns. Here, by devising a laser ablation approach of single oligodendrocytes, followed by in vivo imaging and correlated ultrastructural reconstructions, we report that in mouse cortex demyelination as subtle as the loss of a single oligodendrocyte can trigger robust cell replacement and remyelination ti...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2020
Band / Volume:
11
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-020-18632-0
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32994410
Print-ISSN:
2041-1723
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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