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Titel:

Size-Selective Transfer of Lipid Nanoparticle-Based Drug Carriers Across the Blood Brain Barrier Via Vascular Occlusions Following Traumatic Brain Injury.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Khalin, Igor; Adarsh, Nagappanpillai; Schifferer, Martina; Wehn, Antonia; Groschup, Bernhard; Misgeld, Thomas; Klymchenko, Andrey; Plesnila, Nikolaus
Abstract:
The current lack of understanding about how nanocarriers cross the blood-brain barrier (BBB) in the healthy and injured brain is hindering the clinical translation of nanoscale brain-targeted drug-delivery systems. Here, the bio-distribution of lipid nano-emulsion droplets (LNDs) of two sizes (30 and 80 nm) in the mouse brain after traumatic brain injury (TBI) is investigated. The highly fluorescent LNDs are prepared by loading them with octadecyl rhodamine B and a bulky hydrophobic counter-ion,...     »
Zeitschriftentitel:
Small
Jahr:
2022
Band / Volume:
18
Heft / Issue:
18
Volltext / DOI:
doi:10.1002/smll.202200302
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35384294
Print-ISSN:
1613-6810
TUM Einrichtung:
657; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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