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Titel:

PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma.

Dokumenttyp:
Journal Article
Autor(en):
Wartewig, Tim; Daniels, Jay; Schulz, Miriam; Hameister, Erik; Joshi, Abhinav; Park, Joonhee; Morrish, Emma; Venkatasubramani, Anuroop V; Cernilogar, Filippo M; van Heijster, Frits H A; Hundshammer, Christian; Schneider, Heike; Konstantinidis, Filippos; Gabler, Judith V; Klement, Christine; Kurniawan, Henry; Law, Calvin; Lee, Yujin; Choi, Sara; Guitart, Joan; Forne, Ignasi; Giustinani, Jérôme; Müschen, Markus; Jain, Salvia; Weinstock, David M; Rad, Roland; Ortonne, Nicolas; Schilling, Franz; Scho...     »
Abstract:
The PDCD1-encoded immune checkpoint receptor PD-1 is a key tumor suppressor in T cells that is recurrently inactivated in T cell non-Hodgkin lymphomas (T-NHLs). The highest frequencies of PDCD1 deletions are detected in advanced disease, predicting inferior prognosis. However, the tumor-suppressive mechanisms of PD-1 signaling remain unknown. Here, using tractable mouse models for T-NHL and primary patient samples, we demonstrate that PD-1 signaling suppresses T cell malignancy by restricting gl...     »
Zeitschriftentitel:
Nat. Cancer
Jahr:
2023
Band / Volume:
4
Heft / Issue:
10
Seitenangaben Beitrag:
1508-1525
Volltext / DOI:
doi:10.1038/s43018-023-00635-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37723306
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland); Klinik und Poliklinik für Nuklearmedizin (Prof. Weber); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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