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Titel:

Non-canonical functions of SNAIL drive context-specific cancer progression.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Paul, Mariel C; Schneeweis, Christian; Falcomatà, Chiara; Shan, Chuan; Rossmeisl, Daniel; Koutsouli, Stella; Klement, Christine; Zukowska, Magdalena; Widholz, Sebastian A; Jesinghaus, Moritz; Heuermann, Konstanze K; Engleitner, Thomas; Seidler, Barbara; Sleiman, Katia; Steiger, Katja; Tschurtschenthaler, Markus; Walter, Benjamin; Weidemann, Sören A; Pietsch, Regina; Schnieke, Angelika; Schmid, Roland M; Robles, Maria S; Andrieux, Geoffroy; Boerries, Melanie; Rad, Roland; Schneider, Günter; Saur,...     »
Abstract:
SNAIL is a key transcriptional regulator in embryonic development and cancer. Its effects in physiology and disease are believed to be linked to its role as a master regulator of epithelial-to-mesenchymal transition (EMT). Here, we report EMT-independent oncogenic SNAIL functions in cancer. Using genetic models, we systematically interrogated SNAIL effects in various oncogenic backgrounds and tissue types. SNAIL-related phenotypes displayed remarkable tissue- and genetic context-dependencies, ra...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2023
Band / Volume:
14
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-023-36505-0
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36882420
Print-ISSN:
2041-1723
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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