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Titel:

In vivo functional screening for systems-level integrative cancer genomics.

Dokumenttyp:
Review; Journal Article; Research Support, Non-U.S. Gov't; Review
Autor(en):
Weber, Julia; Braun, Christian J; Saur, Dieter; Rad, Roland
Abstract:
With the genetic portraits of all major human malignancies now available, we next face the challenge of characterizing the function of mutated genes, their downstream targets, interactions and molecular networks. Moreover, poorly understood at the functional level are also non-mutated but dysregulated genomes, epigenomes or transcriptomes. Breakthroughs in manipulative mouse genetics offer new opportunities to probe the interplay of molecules, cells and systemic signals underlying disease pathog...     »
Zeitschriftentitel:
Nat Rev Cancer
Jahr:
2020
Band / Volume:
20
Heft / Issue:
10
Seitenangaben Beitrag:
573-593
Volltext / DOI:
doi:10.1038/s41568-020-0275-9
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32636489
Print-ISSN:
1474-175X
TUM Einrichtung:
611; Lehrstuhl für Experimentelle Tumortherapie (Prof. Saur); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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