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Titel:

Tuning the photophysical properties of cyanine by barbiturate functionalization and nanoformulation for efficient optoacoustics- guided phototherapy.

Dokumenttyp:
Journal Article
Autor(en):
Liu, Nian; O'Connor, Patrick; Gujrati, Vipul; Shelar, Divyesh; Ma, Xiaopeng; Anzenhofer, Pia; Klemm, Uwe; Su, Xinhui; Huang, Yuanhui; Kleigrewe, Karin; Feuchtinger, Annette; Walch, Axel; Sattler, Michael; Plettenburg, Oliver; Ntziachristos, Vasilis
Abstract:
Cyanine derivatives are organic dyes widely used for optical imaging. However, their potential in longitudinal optoacoustic imaging and photothermal therapy remains limited due to challenges such as poor chemical stability, poor photostability, and low photothermal conversion. In this study, we present a new structural modification for cyanine dyes by introducing a strongly electron-withdrawing group (barbiturate), resulting in a new series of barbiturate-cyanine dyes (BC810, BC885, and BC1010)...     »
Zeitschriftentitel:
Journal of Controlled Release
Zeitschriftentitel:
J Control Release
Jahr:
2024
Band / Volume:
372
Seitenangaben Beitrag:
522-530
Volltext / DOI:
doi:10.1016/j.jconrel.2024.06.037
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38897293
WWW:
https://www.sciencedirect.com/science/article/pii/S0168365924003869
Print-ISSN:
0168-3659
TUM Einrichtung:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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