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Titel:

Cardioprotective C-kit? bone marrow cells attenuate apoptosis after acute myocardial infarction in mice - in-vivo assessment with fluorescence molecular imaging.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Ale, Angelique; Siebenhaar, Frank; Kosanke, Katja; Aichler, Michaela; Radrich, Karin; Heydrich, Sina; Schiemann, Matthias; Bielicki, Isabella; Noël, Peter B; Braren, Rickmer; Maurer, Marcus; Walch, Axel K; Rummeny, Ernst J; Ntziachristos, Vasilis; Wildgruber, Moritz
Abstract:
Cardiomyocyte loss via apoptosis plays a crucial role in ventricular remodeling following myocardial infarction (MI). Cell-based therapy approaches using bone marrow derived c-kit? pluripotent cells may attenuate apoptosis following ischemic injury. We therefore thought to examine the early course of apoptosis following myocardial infarction - in-vivo - and non-invasively determine the effect of c-kit? bone marrow cells on post-MI remodeling. We studied apoptosis in wild-type Kit(+/+) , c-kit mu...     »
Zeitschriftentitel:
Theranostics
Jahr:
2013
Band / Volume:
3
Heft / Issue:
11
Seitenangaben Beitrag:
903-13
Sprache:
eng
Volltext / DOI:
doi:10.7150/thno.5938
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24312159
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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