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Titel:

Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single-Cell Resolution

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Englert, Ludwig; Lacalle-Aurioles, Maria; Mohamed, Nguyen-Vi; Lepine, Paula; Mathur, Meghna; Ntziachristos, Vasilis; Durcan, Thomas M.; Aguirre, Juan
Abstract:
Parkinson's disease is a devastating neurodegenerative disorder characterized by loss of neuromelanin-containing dopaminergic neurons. Novel 3D culture systems like human midbrain-like organoids (hMOs) enable new research avenues for patient-specific therapies, but cannot reach their full potential unless rapid optical imaging of entire organoids is enabled. Currently, hMOs have to undergo tissue clearing processes before imaging to overcome light scattering. Since tissue clearing is a lengthy c...     »
Zeitschriftentitel:
Laser & Photonics Reviews
Zeitschriftentitel:
Laser Photon Rev
Jahr:
2023
Band / Volume:
17
Heft / Issue:
8
Volltext / DOI:
doi:10.1002/lpor.202300443
WWW:
https://onlinelibrary.wiley.com/doi/10.1002/lpor.202300443
Print-ISSN:
1863-8880
TUM Einrichtung:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
CC-Lizenz:
by, http://creativecommons.org/licenses/by/4.0
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