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Title:

Longitudinal imaging of T cell-based immunotherapy with multi-spectral, multi-scale optoacoustic tomography.

Document type:
Zeitschriftenaufsatz
Author(s):
Kimm, Melanie A; Tzoumas, Stratis; Glasl, Sarah; Omar, Murad; Symvoulidis, Panagiotis; Olefir, Ivan; Rummeny, Ernst J; Meier, Reinhard; Ntziachristos, Vasilis
Abstract:
Most imaging studies of immunotherapy have focused on tracking labeled T cell biodistribution in vivo for understanding trafficking and homing parameters and predicting therapeutic efficacy by the presence of transferred T cells at or in the tumour mass. Conversely, we investigate here a novel concept for longitudinally elucidating anatomical and pathophysiological changes of solid tumours after adoptive T cell transfer in a preclinical set up, using previously unexplored in-tandem macroscopic a...     »
Journal title:
Scientific Reports
Journal title abbreviation:
Sci Rep
Year:
2020
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41598-020-61191-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32184401
WWW:
https://www.nature.com/articles/s41598-020-61191-z
Print-ISSN:
2045-2322
TUM Institution:
Institut für Diagnostische und Interventionelle Radiologie; Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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