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Title:

Distinctive role of KV1.1 subunit in the biology and functions of low threshold K(+) channels with implications for neurological disease.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review; Review
Author(s):
Ovsepian, Saak V; LeBerre, Marie; Steuber, Volker; O'Leary, Valerie B; Leibold, Christian; Oliver Dolly, J
Abstract:
The diversity of pore-forming subunits of KV1 channels (KV1.1-KV1.8) affords their physiological versatility and predicts a range of functional impairments resulting from genetic aberrations. Curiously, identified so far human neurological conditions associated with dysfunctions of KV1 channels have been linked exclusively to mutations in the KCNA1 gene encoding for the KV1.1 subunit. The absence of phenotypes related to irregularities in other subunits, including the prevalent KV1.2 subunit of...     »
Journal title abbreviation:
Pharmacol Ther
Year:
2016
Journal volume:
159
Pages contribution:
93-101
Language:
eng
Fulltext / DOI:
doi:10.1016/j.pharmthera.2016.01.005
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26825872
Print-ISSN:
0163-7258
TUM Institution:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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