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Title:

Tuning the photophysical properties of cyanine by barbiturate functionalization and nanoformulation for efficient optoacoustics- guided phototherapy.

Document type:
Journal Article
Author(s):
Liu, Nian; O'Connor, Patrick; Gujrati, Vipul; Shelar, Divyesh; Ma, Xiaopeng; Anzenhofer, Pia; Klemm, Uwe; Su, Xinhui; Huang, Yuanhui; Kleigrewe, Karin; Feuchtinger, Annette; Walch, Axel; Sattler, Michael; Plettenburg, Oliver; Ntziachristos, Vasilis
Abstract:
Cyanine derivatives are organic dyes widely used for optical imaging. However, their potential in longitudinal optoacoustic imaging and photothermal therapy remains limited due to challenges such as poor chemical stability, poor photostability, and low photothermal conversion. In this study, we present a new structural modification for cyanine dyes by introducing a strongly electron-withdrawing group (barbiturate), resulting in a new series of barbiturate-cyanine dyes (BC810, BC885, and BC1010)...     »
Journal title:
Journal of Controlled Release
Journal title abbreviation:
J Control Release
Year:
2024
Journal volume:
372
Pages contribution:
522-530
Fulltext / DOI:
doi:10.1016/j.jconrel.2024.06.037
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/38897293
WWW:
https://www.sciencedirect.com/science/article/pii/S0168365924003869
Print-ISSN:
0168-3659
TUM Institution:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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