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Titel:

The endothelial tyrosine phosphatase SHP-1 plays an important role for vascular haemostasis in TNF? -induced inflammation in vivo.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Koch, Elisabeth; Pircher, Joachim; Czermak, Thomas; Gaitzsch, Erik; Alig, Stefan; Mannell, Hanna; Niemeyer, Markus; Krötz, Florian; Wörnle, Markus
Abstract:
Inflammation and endothelium-derived superoxides are important pathomechanisms in atherothrombotic diseases. We could previously show that the tyrosine phosphatase SHP-1 acts as a negative regulator in endothelial superoxide production. In this study we investigated the influence of SHP-1 on platelet-endothelium interaction and arterial thrombosis in TNF? -induced endothelial inflammation in vivo.Arteriolar thrombosis and platelet rolling in vivo were investigated in C57BL/6 mice using intravita...     »
Zeitschriftentitel:
Mediators Inflamm
Jahr:
2013
Band / Volume:
2013
Seitenangaben Beitrag:
279781
Sprache:
eng
Volltext / DOI:
doi:10.1155/2013/279781
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23766558
Print-ISSN:
0962-9351
TUM Einrichtung:
Frauenklinik und Poliklinik; Klinik für Anästhesiologie (DHM)
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