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Titel:

Maternal diabetes leads to unphysiological high lipid accumulation in rabbit preimplantation embryos.

Dokumenttyp:
journal article
Autor(en):
Schindler, Maria, M; Pendzialek, Mareike, M; Navarrete Santos, Alexander, A; Plösch, Torsten, T; Seyring, Stefanie, S; Gürke, Jacqueline, J; Haucke, Elisa, E; Knelangen, Julia Miriam, JM; Fischer, Bernd, B; Santos, Anne Navarrete, AN
Abstract:
According to the "developmental origin of health and disease" hypothesis, the metabolic set points of glucose and lipid metabolism are determined prenatally. In the case of a diabetic pregnancy, the embryo is exposed to higher glucose and lipid concentrations as early as during preimplantation development. We used the rabbit to study the effect of maternal diabetes type 1 on lipid accumulation and expression of lipogenic markers in preimplantation blastocysts. Accompanied by elevated triglycerid...     »
Zeitschriftentitel:
Endocrinology
Jahr:
2014
Band / Volume:
155
Heft / Issue:
4
Seitenangaben Beitrag:
1498-509
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24428528
Print-ISSN:
0013-7227
TUM Einrichtung:
Institut für Virologie
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