Virology. Response to Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".

Titel:: Virology. Response to Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".
Dokumenttyp:: Comment; Journal Article; Research Support, Non-U.S. Gov't; Editorial Material
Autor(en):: Xia, Yuchen; Lucifora, Julie; Reisinger, Florian; Heikenwälder, Mathias; Protzer, Ulrike
Abstract:: Chisari et al. challenge our central conclusion that the hepatitis B virus (HBV) persistent form, the covalently closed circular DNA (cccDNA), is degraded in a noncytotoxic and specific fashion in the nucleus of infected hepatocytes. Specificity of the assays used, exclusion of cell division or death, and activity of APOBEC3 deaminases in the nucleus, however, were addressed in the paper.
Zeitschriftentitel:: Science
Jahr:: 2014
Band / Volume:: 344
Heft / Issue:: 6189
Seitenangaben Beitrag:: 1237
Sprache:: eng
Volltext / DOI:: doi:10.1126/science.1254083
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/24926011
Print-ISSN:: 0036-8075
TUM Einrichtung:: Institut für Virologie
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