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Titel:

Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Lucifora, Julie; Xia, Yuchen; Reisinger, Florian; Zhang, Ke; Stadler, Daniela; Cheng, Xiaoming; Sprinzl, Martin F; Koppensteiner, Herwig; Makowska, Zuzanna; Volz, Tassilo; Remouchamps, Caroline; Chou, Wen-Min; Thasler, Wolfgang E; Hüser, Norbert; Durantel, David; Liang, T Jake; Münk, Carsten; Heim, Markus H; Browning, Jeffrey L; Dejardin, Emmanuel; Dandri, Maura; Schindler, Michael; Heikenwälder, Mathias; Protzer, Ulrike
Abstract:
Current antiviral agents can control but not eliminate hepatitis B virus (HBV), because HBV establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-? treatment can clear HBV but is limited by systemic side effects. We describe how interferon-? can induce specific degradation of the nuclear viral DNA without hepatotoxicity and propose lymphotoxin-? receptor activation as a therapeutic alternative. Interferon-? and lymphotoxin-? receptor activation up-regulated APOBEC3A an...     »
Zeitschriftentitel:
Science
Jahr:
2014
Band / Volume:
343
Heft / Issue:
6176
Seitenangaben Beitrag:
1221-8
Sprache:
eng
Volltext / DOI:
doi:10.1126/science.1243462
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24557838
Print-ISSN:
0036-8075
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Virologie
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