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Title:

Hepatitis B virus infection enhances susceptibility toward adeno-associated viral vector transduction in vitro and in vivo.

Document type:
Journal Article; Article
Author(s):
Hösel, Marianna; Lucifora, Julie; Michler, Thomas; Holz, Gisela; Gruffaz, Marion; Stahnke, Stephanie; Zoulim, Fabien; Durantel, David; Heikenwälder, Mathias; Nierhoff, Dirk; Millet, Rachel; Salvetti, Anna; Protzer, Ulrike; Büning, Hildegard
Abstract:
Gene therapy has become an accepted concept for the treatment of a variety of different diseases. In contrast to preclinical models, subjects enrolled in clinical trials, including gene therapy, possess a history of infection with microbes that may influence its safety and efficacy. Especially, viruses that establish chronic infections in the liver, one of the main targets for in vivo gene therapy, raise important concerns. Among them is the hepatitis B virus (HBV), which has chronically infecte...     »
Journal title abbreviation:
Hepatology
Year:
2014
Journal volume:
59
Journal issue:
6
Pages contribution:
2110-20
Language:
eng
Fulltext / DOI:
doi:10.1002/hep.26990
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24425003
Print-ISSN:
0270-9139
TUM Institution:
Institut für Virologie
 BibTeX