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Title:

Analysis of determinants in filovirus glycoproteins required for tetherin antagonism.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Gnirß, Kerstin; Fiedler, Marie; Krämer-Kühl, Annika; Bolduan, Sebastian; Mittler, Eva; Becker, Stephan; Schindler, Michael; Pöhlmann, Stefan
Abstract:
The host cell protein tetherin can restrict the release of enveloped viruses from infected cells. The HIV-1 protein Vpu counteracts tetherin by removing it from the site of viral budding, the plasma membrane, and this process depends on specific interactions between the transmembrane domains of Vpu and tetherin. In contrast, the glycoproteins (GPs) of two filoviruses, Ebola and Marburg virus, antagonize tetherin without reducing surface expression, and the domains in GP required for tetherin cou...     »
Journal title abbreviation:
Viruses
Year:
2014
Journal volume:
6
Journal issue:
4
Pages contribution:
1654-71
Language:
eng
Fulltext / DOI:
doi:10.3390/v6041654
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24721789
Print-ISSN:
1999-4915
TUM Institution:
Institut für Virologie
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