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Title:

Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Journal Article
Author(s):
Gewies, Andreas; Gorka, Oliver; Bergmann, Hanna; Pechloff, Konstanze; Petermann, Franziska; Jeltsch, Katharina M; Rudelius, Martina; Kriegsmann, Mark; Weichert, Wilko; Horsch, Marion; Beckers, Johannes; Wurst, Wolfgang; Heikenwälder, Mathias; Korn, Thomas; Heissmeyer, Vigo; Ruland, Jürgen
Abstract:
The paracaspase Malt1 is a central regulator of antigen receptor signaling that is frequently mutated in human lymphoma. As a scaffold, it assembles protein complexes for NF-?B activation, and its proteolytic domain cleaves negative NF-?B regulators for signal enforcement. Still, the physiological functions of Malt1-protease are unknown. We demonstrate that targeted Malt1-paracaspase inactivation induces a lethal inflammatory syndrome with lymphocyte-dependent neurodegeneration in vivo. Paracasp...     »
Journal title abbreviation:
Cell Rep
Year:
2014
Journal volume:
9
Journal issue:
4
Pages contribution:
1292-305
Language:
eng
Fulltext / DOI:
doi:10.1016/j.celrep.2014.10.044
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25456129
Print-ISSN:
2211-1247
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Institut für Virologie ; Neurologische Klinik und Poliklinik
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