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Title:

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.

Document type:
Journal Article; Article
Author(s):
Vogel, KU; Edelmann, SL; Jeltsch, KM; Bertossi, A; Heger, K; Heinz, GA; Zöller, J; Warth, SC; Hoefig, KP; Lohs, C; Neff, F; Kremmer, E; Schick, J; Repsilber, D; Geerlof, A; Blum, H; Wurst, W; Heikenwalder, M; Schmidt-Supprian, M; Heissmeyer, V
Abstract:
The Roquin-1 protein binds to messenger RNAs (mRNAs) and regulates gene expression posttranscriptionally. A single point mutation in Roquin-1, but not gene ablation, increases follicular helper T (Tfh) cell numbers and causes lupus-like autoimmune disease in mice. In T cells, we did not identify a unique role for the much lower expressed paralog Roquin-2. However, combined ablation of both genes induced accumulation of T cells with an effector and follicular helper phenotype. We showed that Roqu...     »
Journal title abbreviation:
Immunity
Year:
2013
Journal volume:
38
Journal issue:
4
Pages contribution:
655-68
Language:
eng
Fulltext / DOI:
doi:10.1016/j.immuni.2012.12.004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23583643
Print-ISSN:
1074-7613
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Virologie
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