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Title:

The cyclic GMP-dependent protein kinase I? suppresses kidney fibrosis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Schinner, Elisabeth; Schramm, Andrea; Kees, Frieder; Hofmann, Franz; Schlossmann, Jens
Abstract:
Cyclic guanosine monophosphate (cGMP) is synthesized by nitric oxide or natriuretic peptide-stimulated guanylyl cyclases and exhibits pleiotropic regulatory functions in the kidney. Hence, integration of cGMP signaling by cGMP-dependent protein kinases (cGKs) might play a critical role in renal physiology; however, detailed renal localization of cGKs is still lacking. Here, we performed an immunohistochemical analysis of cGKI? and cGKI? isozymes in the mouse kidney and found both in arterioles,...     »
Journal title abbreviation:
Kidney Int
Year:
2013
Journal volume:
84
Journal issue:
6
Pages contribution:
1198-206
Language:
eng
Fulltext / DOI:
doi:10.1038/ki.2013.219
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23760283
Print-ISSN:
0085-2538
TUM Institution:
Institut für Pharmakologie und Toxikologie
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