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Titel:

Intraductal papillary neoplasms of the bile duct: stepwise progression to carcinoma involves common molecular pathways.

Dokumenttyp:
Journal Article; Article
Autor(en):
Schlitter, Anna Melissa; Born, Diana; Bettstetter, Marcus; Specht, Katja; Kim-Fuchs, Corina; Riener, Marc-Oliver; Jeliazkova, Petia; Sipos, Bence; Siveke, Jens T; Terris, Benoit; Zen, Yoh; Schuster, Tibor; Höfler, Heinz; Perren, Aurel; Klöppel, Günter; Esposito, Irene
Abstract:
Intraductal papillary neoplasms of the bile duct are still poorly characterized regarding (1) their molecular alterations during the development to invasive carcinomas, (2) their subtype stratification and (3) their biological behavior. We performed a multicenter study that analyzed these issues in a large European cohort. Intraductal papillary neoplasms of the bile duct from 45 patients were graded and subtyped using mucin markers and CDX2. In addition, tumors were analyzed for common oncogenic...     »
Zeitschriftentitel:
Mod Pathol
Jahr:
2014
Band / Volume:
27
Heft / Issue:
1
Seitenangaben Beitrag:
73-86
Sprache:
eng
Volltext / DOI:
doi:10.1038/modpathol.2013.112
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23828315
Print-ISSN:
0893-3952
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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