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Title:

Towards the generation of B-cell receptor retrogenic mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Freitag, Jenny; Heink, Sylvia; Roth, Edith; Wittmann, Jürgen; Jäck, Hans-Martin; Kamradt, Thomas
Abstract:
Transgenic expression of B- and T-cell receptors (BCRs and TCRs, respectively) has been a standard tool to study lymphocyte development and function in vivo. The generation of transgenic mice is time-consuming and, therefore, a faster method to study the biology of defined lymphocyte receptors in vivo would be highly welcome. Using 2A peptide-linked multicistronic retroviral vectors to transduce stem cells, TCRs can be expressed rapidly in mice of any background. We aimed at adopting this retrog...     »
Journal title abbreviation:
PLoS ONE
Year:
2014
Journal volume:
9
Journal issue:
10
Pages contribution:
e109199
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0109199
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25296340
Print-ISSN:
1932-6203
TUM Institution:
Neurologische Klinik und Poliklinik
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