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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Kaebisch, Romy; Mejías-Luque, Raquel; Prinz, Christian; Gerhard, Markus
Titel:
Helicobacter pylori cytotoxin-associated gene A impairs human dendritic cell maturation and function through IL-10-mediated activation of STAT3.
Abstract:
Helicobacter pylori infection induces chronic gastric inflammation that can progress to cancer. In this process, the virulence factor cytotoxin-associated gene A (CagA) plays a central role by directly altering epithelial cell signaling and inducing a strong Th1 immune response, which contributes to carcinogenesis. It is still barely understood how the bacterium evades clearance despite this solid immune response and persists lifelong. Dendritic cells (DCs) play a major role in determining the a...     »
Zeitschriftentitel:
J Immunol
Jahr:
2014
Band / Volume:
192
Heft / Issue:
1
Seitenangaben Beitrag:
316-23
Sprache:
eng
Volltext / DOI:
doi:10.4049/jimmunol.1302476
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24293633
Print-ISSN:
0022-1767
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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