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Title:

Functional relevance of NLRP3 inflammasome-mediated interleukin (IL)-1? during acute allergic airway inflammation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ritter, M; Straubinger, K; Schmidt, S; Busch, D H; Hagner, S; Garn, H; Prazeres da Costa, C; Layland, L E
Abstract:
Overall asthmatic symptoms can be controlled with diverse therapeutic agents. However, certain symptomatic individuals remain at risk for serious morbidity and mortality, which prompts the identification of novel therapeutic targets and treatment strategies. Thus, using an adjuvant-free T helper type 2 (Th2) murine model, we have deciphered the role of interleukin (IL)-1 signalling during allergic airway inflammation (AAI). Because functional IL-1? depends on inflammasome activation we first stu...     »
Journal title abbreviation:
Clin Exp Immunol
Year:
2014
Journal volume:
178
Journal issue:
2
Pages contribution:
212-23
Language:
eng
Fulltext / DOI:
doi:10.1111/cei.12400
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24943899
Print-ISSN:
0009-9104
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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