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Title:

Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Whitney, Paul G; Bär, Eva; Osorio, Fabiola; Rogers, Neil C; Schraml, Barbara U; Deddouche, Safia; LeibundGut-Landmann, Salome; Reis E Sousa, Caetano
Abstract:
Host protection from fungal infection is thought to ensue in part from the activity of Syk-coupled C-type lectin receptors and MyD88-coupled toll-like receptors in myeloid cells, including neutrophils, macrophages and dendritic cells (DCs). Given the multitude of cell types and receptors involved, elimination of a single pathway for fungal recognition in a cell type such as DCs, primarily known for their ability to prime T cell responses, would be expected to have little effect on innate resista...     »
Journal title abbreviation:
PLoS Pathog
Year:
2014
Journal volume:
10
Journal issue:
7
Pages contribution:
e1004276
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.ppat.1004276
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25033445
Print-ISSN:
1553-7366
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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