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Title:

B-cell-intrinsic STAT6 signaling controls germinal center formation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Turqueti-Neves, Adriana; Otte, Manuel; Prazeres da Costa, Olivia; Höpken, Uta E; Lipp, Martin; Buch, Thorsten; Voehringer, David
Abstract:
Infection with helminths and exposure to antigens induce a strong type 2 immune response resulting in the secretion of the cytokines IL-4 and IL-13 by CD4(+) T cells and several innate cell types. IL-4 and IL-13 promote class switch recombination to IgG1 and IgE while their role for germinal center (GC) formation is poorly understood. We found a dramatic reduction in the numbers of GC B cells when investigating different type 2 immune responses in IL-4/IL-13-deficient mice. IL-4/IL-13 from T cel...     »
Journal title abbreviation:
Eur J Immunol
Year:
2014
Journal volume:
44
Journal issue:
7
Pages contribution:
2130-8
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.201344203
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24777733
Print-ISSN:
0014-2980
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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