Benutzer: Gast  Login
Titel:

Clinical-scale isolation of 'minimally manipulated' cytomegalovirus-specific donor lymphocytes for the treatment of refractory cytomegalovirus disease.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Odendahl, Marcus; Grigoleit, G Ulrich; Bonig, Halvard; Neuenhahn, Michael; Albrecht, Julia; Anderl, Florian; Germeroth, Lothar; Schmitz, Marc; Bornhäuser, Martin; Einsele, Hermann; Seifried, Erhard; Busch, Dirk H; Tonn, Torsten
Abstract:
Reactivation of cytomegalovirus (CMV) after hematopoietic stem cell transplantation remains a major cause of morbidity despite improved antiviral drug therapies. Selective restoration of CMV immunity by adoptive transfer of CMV-specific T cells is the only alternative approach that has been shown to be effective and non-toxic. We describe the results of clinical-scale isolations of CMV-specific donor lymphocytes with the use of a major histocompatibility (MHC) class I peptide streptamer-based is...     »
Zeitschriftentitel:
Cytotherapy
Jahr:
2014
Band / Volume:
16
Heft / Issue:
9
Seitenangaben Beitrag:
1245-56
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jcyt.2014.05.023
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25108651
Print-ISSN:
1465-3249
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX