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Titel:

Maternal immune response to helminth infection during pregnancy determines offspring susceptibility to allergic airway inflammation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Straubinger, Kathrin; Paul, Sabine; Prazeres da Costa, Olivia; Ritter, Manuel; Buch, Thorsten; Busch, Dirk H; Layland, Laura E; Prazeres da Costa, Clarissa U
Abstract:
Schistosomiasis, a chronic helminth infection, elicits distinct immune responses within the host, ranging from an initial TH1 and subsequent TH2 phase to a regulatory state, and is associated with dampened allergic reactions within the host.We sought to evaluate whether non-transplacental helminth infection during pregnancy alters the offspring's susceptibility to allergy.Ovalbumin-induced allergic airway inflammation was analyzed in offspring from Schistosoma mansoni-infected mothers mated duri...     »
Zeitschriftentitel:
J Allergy Clin Immunol
Jahr:
2014
Band / Volume:
134
Heft / Issue:
6
Seitenangaben Beitrag:
1271-1279.e10
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jaci.2014.05.034
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25042744
Print-ISSN:
0091-6749
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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