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Title:

A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Rosemann, Michael; Gonzalez-Vasconcellos, Iria; Domke, Tanja; Kuosaite, Virginija; Schneider, Ralf; Kremer, Markus; Favor, Jack; Nathrath, Michaela; Atkinson, Michael J
Abstract:
Syndromic forms of osteosarcoma (OS) account for less than 10% of all recorded cases of this malignancy. An individual OS predisposition is also possible by the inheritance of low penetrance alleles of tumor susceptibility genes, usually without evidence of a syndromic condition. Genetic variants involved in such a non-syndromic form of tumor predisposition are difficult to identify, given the low incidence of osteosarcoma cases and the genetic heterogeneity of patients. We recently mapped a maj...     »
Journal title abbreviation:
Mol Cancer
Year:
2014
Journal volume:
13
Pages contribution:
182
Language:
eng
Fulltext / DOI:
doi:10.1186/1476-4598-13-182
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25092376
Print-ISSN:
1476-4598
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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