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Titel:

Salinomycin increases chemosensitivity to the effects of doxorubicin in soft tissue sarcomas.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Liffers, Sven-T; Tilkorn, Daniel J; Stricker, Ingo; Junge, Christoph Günter; Al-Benna, Sammy; Vogt, Markus; Verdoodt, Berlinda; Steinau, Hans-U; Tannapfel, Andrea; Tischoff, Iris; Mirmohammadsadegh, Alireza
Abstract:
Chemotherapy for soft tissue sarcomas remains unsatisfactory due to their low chemosensitivity. Even the first line chemotherapeutic agent doxorubicin only yields a response rate of 18-29%. The antibiotic salinomycin, a potassium ionophore, has recently been shown to be a potent compound to deplete chemoresistant cells like cancer stem like cells (CSC) in adenocarcinomas. Here, we evaluated the effect of salinomycin on sarcoma cell lines, whereby salinomycin mono- and combination treatment with...     »
Zeitschriftentitel:
BMC Cancer
Jahr:
2013
Band / Volume:
13
Seitenangaben Beitrag:
490
Sprache:
eng
Volltext / DOI:
doi:10.1186/1471-2407-13-490
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24144362
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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