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Titel:

How microRNA and transcription factor co-regulatory networks affect osteosarcoma cell proliferation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Poos, Kathrin; Smida, Jan; Nathrath, Michaela; Maugg, Doris; Baumhoer, Daniel; Korsching, Eberhard
Abstract:
Osteosarcomas (OS) are complex bone tumors with various genomic alterations. These alterations affect the expression and function of several genes due to drastic changes in the underlying gene regulatory network. However, we know little about critical gene regulators and their functional consequences on the pathogenesis of OS. Therefore, we aimed to determine microRNA and transcription factor (TF) co-regulatory networks in OS cell proliferation. Cell proliferation is an essential part in the pat...     »
Zeitschriftentitel:
PLoS Comput Biol
Jahr:
2013
Band / Volume:
9
Heft / Issue:
8
Seitenangaben Beitrag:
e1003210
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pcbi.1003210
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24009496
Print-ISSN:
1553-734X
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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