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Document type:
Journal Article; Article
Author(s):
Hauer, K; Calzada-Wack, J; Steiger, K; Grunewald, TG; Baumhoer, D; Plehm, S; Buch, T; Prazeres da Costa, O; Esposito, I; Burdach, S; Richter, GH
Title:
DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma.
Abstract:
Ewing sarcoma, an osteolytic malignancy that mainly affects children and young adults, is characterized by early metastasis to lung and bone. In this study, we identified the pro-metastatic gene DKK2 as a highly overexpressed gene in Ewing sarcoma compared with corresponding normal tissues. Using RNA interference, we showed that DKK2 was critical for malignant cell outgrowth in vitro and in an orthotopic xenograft mouse model in vivo. Analysis of invasion potential in both settings revealed a st...     »
Journal title abbreviation:
Cancer Res
Year:
2013
Journal volume:
73
Journal issue:
2
Pages contribution:
967-77
Language:
eng
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-12-1492
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23204234
Print-ISSN:
0008-5472
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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