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Titel:

Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation.

Dokumenttyp:
Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Article
Autor(en):
Schlenk, Richard F; Kayser, Sabine; Bullinger, Lars; Kobbe, Guido; Casper, Jochen; Ringhoffer, Mark; Held, Gerhard; Brossart, Peter; Lübbert, Michael; Salih, Helmut R; Kindler, Thomas; Horst, Heinz A; Wulf, Gerald; Nachbaur, David; Götze, Katharina; Lamparter, Alexander; Paschka, Peter; Gaidzik, Verena I; Teleanu, Veronica; Späth, Daniela; Benner, Axel; Krauter, Jürgen; Ganser, Arnold; Döhner, Hartmut; Döhner, Konstanze
Abstract:
The objective was to evaluate the prognostic and predictive impact of allelic ratio and insertion site (IS) of internal tandem duplications (ITDs), as well as concurrent gene mutations, with regard to postremission therapy in 323 patients with FLT3-ITD-positive acute myeloid leukemia (AML). Increasing FLT3-ITD allelic ratio (P = .004) and IS in the tyrosine kinase domain 1 (TKD1, P = .06) were associated with low complete remission (CR) rates. After postremission therapy including intensive chem...     »
Zeitschriftentitel:
Blood
Jahr:
2014
Band / Volume:
124
Heft / Issue:
23
Seitenangaben Beitrag:
3441-9
Sprache:
eng
Volltext / DOI:
doi:10.1182/blood-2014-05-578070
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25270908
Print-ISSN:
0006-4971
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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