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Titel:

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Rokavec, Matjaz; Öner, Meryem Gülfem; Li, Huihui; Jackstadt, Rene; Jiang, Longchang; Lodygin, Dmitri; Kaller, Markus; Horst, David; Ziegler, Paul K; Schwitalla, Sarah; Slotta-Huspenina, Julia; Bader, Franz G; Greten, Florian R; Hermeking, Heiko
Abstract:
Members of the miR-34 family are induced by the tumor suppressor p53 and are known to inhibit epithelial-to-mesenchymal transition (EMT) and therefore presumably suppress the early phases of metastasis. Here, we determined that exposure of human colorectal cancer (CRC) cells to the cytokine IL-6 activates the oncogenic STAT3 transcription factor, which directly represses the MIR34A gene via a conserved STAT3-binding site in the first intron. Repression of MIR34A was required for IL-6-induced EMT...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2014
Band / Volume:
124
Heft / Issue:
4
Seitenangaben Beitrag:
1853-67
Sprache:
eng
Volltext / DOI:
doi:10.1172/JCI73531
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24642471
Print-ISSN:
0021-9738
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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