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Title:

Multicenter Immunohistochemical ALK-Testing of Non-Small-Cell Lung Cancer Shows High Concordance after Harmonization of Techniques and Interpretation Criteria.

Document type:
Journal Article
Author(s):
von Laffert, Maximilian; Warth, Arne; Penzel, Roland; Schirmacher, Peter; Kerr, Keith M; Elmberger, Göran; Schildhaus, Hans-Ulrich; Büttner, Reinhard; López-Ríos, Fernando; Reu, Simone; Kirchner, Thomas; Pauwels, Patrick; Specht, Katja; Drecoll, Enken; Höfler, Heinz; Aust, Daniela; Baretton, Gustavo; Bubendorf, Lukas; Stallmann, Sonja; Fisseler-Eckhoff, Annette; Soltermann, Alex; Tischler, Verena; Moch, Holger; Penault-Llorca, Frederique; Hager, Hendrik; Schäper, Frank; Lenze, Dido; Hummel, Mich...     »
Abstract:
Detection of anaplastic lymphoma kinase (ALK)-gene rearrangements in non-small-cell lung cancer (NSCLC) is mainly performed by fluorescence in-situ hybridization (FISH). The question was raised if FISH might be replaced by immunohistochemistry (IHC) in a reliable and reproducible manner across different laboratories.After calibration of the staining instruments and training of the observers to binary interpretation (positive versus negative), 15 NSCLC were independently tested for ALK protein ex...     »
Journal title abbreviation:
J Thorac Oncol
Year:
2014
Journal volume:
9
Journal issue:
11
Pages contribution:
1685-1692
Language:
eng
Fulltext / DOI:
doi:10.1097/JTO.0000000000000332
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25436802
Print-ISSN:
1556-0864
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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